Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8076856 | 0.89 | MAPT (0.53) | MAPTALDH1A1HPGDKDM4ECYP1A2 | |
| SCHEMBL3963167 | 0.86 | MEN1 (0.59) | MAPTALDH1A1HPGDKDM4ECYP1A2 | |
| SCHEMBL8071688 | 0.84 | MAPT (0.53) | MAPTALDH1A1HPGDKDM4ECYP1A2 | |
| SCHEMBL31616073 | 0.83 | ALDH1A1 (0.56) | MAPTALDH1A1HPGDKDM4ECYP1A2 | |
| SCHEMBL17223430 | 0.79 | SMN1; SMN2 (0.65) | MAPTALDH1A1HPGDCYP2C9CYP2C19 | |
| SCHEMBL17302741 | 0.78 | ALDH1A1 (0.67) | MAPTALDH1A1HPGDKDM4ECYP1A2 | |
| SCHEMBL8073516 | 0.76 | MAPT (0.55) | MAPTALDH1A1HPGDCYP2C9CYP2C19 | |
| SCHEMBL17302717 | 0.76 | MAPT (0.69) | MAPTALDH1A1HPGDKDM4ECYP2C9 | |
| SCHEMBL14334514 | 0.74 | MAPT (0.66) | MAPTALDH1A1HPGDKDM4ECYP1A2 | |
| SCHEMBL14009560 | 0.73 | DDR1 (0.50) | ALDH1A1KDM4EGAALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080221132-A1 | Multi-Functional Small Molecules as Anti-Proliferative Agents | CURIS, INC. | 2008-09-11 | — | — | US | disclosed |
| US-20080221132-A1 | Multi-Functional Small Molecules as Anti-Proliferative Agents | CURIS, INC. | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221132-A1 | Multi-Functional Small Molecules as Anti-Proliferative Agents | HDAC1, HDAC6, HDAC5 | MAPT 3758/4885ALDH1A1 2328/4885HPGD 2142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.