Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.53 |
| ▸ | HPGD | P15428 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14067166 | 0.89 | MAPT (0.53) | MAPTALDH1A1HPGDKDM4ECYP2C9 | |
| SCHEMBL8071688 | 0.84 | MAPT (0.53) | MAPTALDH1A1HPGDKDM4ECYP2C9 | |
| SCHEMBL31616073 | 0.83 | ALDH1A1 (0.56) | MAPTALDH1A1HPGDKDM4ECYP2C9 | |
| SCHEMBL17223430 | 0.79 | SMN1; SMN2 (0.65) | MAPTALDH1A1HPGDCYP2C9CYP2C19 | |
| SCHEMBL17302741 | 0.78 | ALDH1A1 (0.67) | MAPTALDH1A1HPGDKDM4ECYP2C9 | |
| SCHEMBL17302717 | 0.76 | MAPT (0.69) | MAPTALDH1A1HPGDKDM4ECYP2C9 | |
| SCHEMBL8073516 | 0.76 | MAPT (0.55) | MAPTALDH1A1HPGDCYP2C9CYP2C19 | |
| SCHEMBL3963167 | 0.74 | MEN1 (0.59) | MAPTALDH1A1HPGDKDM4ECYP2C9 | |
| SCHEMBL14334514 | 0.74 | MAPT (0.66) | MAPTALDH1A1HPGDKDM4ECYP2C9 | |
| SCHEMBL102545 | 0.72 | MAPT (0.60) | MAPTALDH1A1HPGDKDM4ECYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009036051-A1 | BCL-2 INHIBITORS CONTAINING A ZINC BINDING MOIETY | CURIS, INC. (US) | 2009-03-19 | — | — | WO | disclosed |
| WO-2008033747-A9 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | CURIS INC (MA) | 2008-07-24 | — | — | WO | disclosed |
| WO-2008033747-A2 | MULTI-FUNCTIONAL SMALL MOLECULES AS ANTI-PROLIFERATIVE AGENTS | CURIS, INC. (US) | 2008-03-20 | — | — | WO | disclosed |