Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 5/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.58 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | KDM5A | P29375 | 1/20 | 0.56 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.50 |
| ▸ | PTAFR | P25105 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | MERTK | Q12866 | 1/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8062288 | 0.88 | EPHX2 (0.74) | GRM5EPHX2SMYD3KDM4EGAA | |
| SCHEMBL25053100 | 0.86 | GRM5 (0.63) | GRM5EPHX2SMYD3KDM4EGAA | |
| SCHEMBL2241357 | 0.84 | GRM5 (0.77) | GRM5EPHX2SMYD3KDM4EGAA | |
| SCHEMBL8062282 | 0.83 | EPHX2 (0.76) | GRM5EPHX2SMYD3KDM4EGAA | |
| SCHEMBL8063381 | 0.83 | USP30 (0.68) | GRM5EPHX2SMYD3KDM5AEPHX1 | |
| SCHEMBL8063384 | 0.83 | KDM5A (0.70) | GRM5EPHX2SMYD3KDM4EGAA | |
| SCHEMBL5315579 | 0.83 | SMYD3 (0.60) | GRM5EPHX2SMYD3KDM4EGAA | |
| SCHEMBL5316723 | 0.83 | GRM5 (0.59) | GRM5EPHX2SMYD3KDM4EGAA | |
| SCHEMBL14625979 | 0.82 | GRM5 (0.62) | GRM5EPHX2SMYD3KDM4EGAA | |
| SCHEMBL31654067 | 0.81 | GRM5 (0.60) | GRM5EPHX2SMYD3KDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1325910-B1 | ALIPHATIC NITROGENOUS FIVE-MEMBERED RING COMPOUNDS | MITSUBISHI TANABE PHARMA CORP (JP) | 2008-09-17 | — | — | EP | disclosed |
| US-7160877-B2 | Aliphatic nitrogen-containing 5-membered ring compound | TANABE SEIYAKU CO., LTD. (JP) | 2007-01-09 | — | — | US | disclosed |