Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.59 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | KDM5A | P29375 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.53 |
| ▸ | F10 | P00742 | 7/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25053100 | 0.85 | GRM5 (0.63) | GRM5SMYD3ALDH1A1KDM5AKMT2A | |
| SCHEMBL2241357 | 0.83 | GRM5 (0.77) | GRM5SMYD3KMT2AKDM4EGAA | |
| SCHEMBL14067296 | 0.83 | GRM5 (0.60) | GRM5SMYD3KDM5AKMT2AKDM4E | |
| SCHEMBL5315579 | 0.82 | SMYD3 (0.60) | GRM5SMYD3KDM5AKMT2AKDM4E | |
| SCHEMBL8062288 | 0.81 | EPHX2 (0.74) | GRM5SMYD3KDM5AKMT2AKDM4E | |
| SCHEMBL14625979 | 0.81 | GRM5 (0.62) | GRM5SMYD3KDM5AKMT2AKDM4E | |
| SCHEMBL17132549 | 0.81 | SMYD3 (0.62) | GRM5SMYD3ALDH1A1KDM5AKMT2A | |
| SCHEMBL31654067 | 0.80 | GRM5 (0.60) | GRM5SMYD3KDM5AKMT2AKDM4E | |
| SCHEMBL356606 | 0.80 | GRM5 (0.60) | GRM5SMYD3KDM5AKMT2AKDM4E | |
| SCHEMBL16394406 | 0.80 | GRM5 (0.88) | GRM5SMYD3KMT2AKDM4EGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069053-A1 | BENZIMIDAZOLE ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-06-21 | — | — | WO | claimed |
| WO-2007069053-A1 | BENZIMIDAZOLE ANTAGONISTS OF THE H-3 RECEPTOR | PFIZER PRODUCTS INC. (US) | 2007-06-21 | — | — | WO | disclosed |