Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.48 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 3/20 | 0.45 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 6/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | SCD | O00767 | 2/20 | 0.41 |
| ▸ | TDO2 | P48775 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14067370 | 0.86 | TLR9 (0.47) | TLR9TLR7SMN1; SMN2TP53APP | |
| SCHEMBL14067405 | 0.84 | APP (0.42) | TLR9TLR7SMN1; SMN2TP53APP | |
| SCHEMBL14067364 | 0.83 | APP (0.67) | SMN1; SMN2APPNPC1RAB9AKDM4E | |
| SCHEMBL14067381 | 0.82 | APP (0.43) | TLR9SMN1; SMN2TP53APPNPC1 | |
| SCHEMBL14067403 | 0.82 | APP (0.44) | TLR9TLR7SMN1; SMN2TP53APP | |
| SCHEMBL14067400 | 0.78 | APP (0.41) | TLR9TLR7SMN1; SMN2TP53APP | |
| SCHEMBL14067382 | 0.77 | APP (0.43) | TLR9TLR7SMN1; SMN2TP53APP | |
| SCHEMBL14067385 | 0.77 | NPC1 (0.44) | SMN1; SMN2TP53APPNPC1RAB9A | |
| SCHEMBL30309564 | 0.75 | HDAC6 (0.65) | TLR9TLR7SMN1; SMN2TP53BACE1 | |
| SCHEMBL3431380 | 0.75 | APP (0.67) | SMN1; SMN2APPNPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080219922-A1 | Alzheimer's Disease Imaging Agents | EMORY UNIVERSITY | 2008-09-11 | — | — | US | disclosed |
| US-20080219922-A1 | Alzheimer's Disease Imaging Agents | EMORY UNIVERSITY | 2008-09-11 | — | — | US | disclosed |
| WO-2007033080-A2 | ALZHEIMER'S DISEASE IMAGING AGENTS | EMORY UNIVERSITY (US) | 2007-03-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080219922-A1 | Alzheimer's Disease Imaging Agents | APP, PSEN1, MAPT | TLR9 4883/4885TLR7 4871/4885SMN1; SMN2 1690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.