Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14483300 | 0.80 | MEN1 (0.61) | PDE4DMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL2559503 | 0.79 | PDE4D (0.56) | PDE4DMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL12264899 | 0.78 | PDE4D (0.59) | PDE4DMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL2554005 | 0.78 | PDE4D (0.55) | PDE4DMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL23399943 | 0.70 | KDM4C (0.55) | PDE4DMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL12266477 | 0.69 | ALDH1A1 (0.49) | PDE4DMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL14482912 | 0.69 | MEN1 (0.47) | PDE4DMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL2576433 | 0.68 | TSHR (0.47) | PDE4DMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL14482214 | 0.68 | PDE4D (0.47) | PDE4DMEN1KMT2ARAB9ANPC1 | |
| SCHEMBL4524302 | 0.68 | GAA (0.57) | PDE4DMEN1KMT2ARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1343781-B1 | INHIBITORS OF C-JUN N-TERMINAL KINASES (JNK) AND OTHER PROTEIN KINASES | VERTEX PHARMA (US) | 2008-09-03 | — | — | EP | disclosed |