Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.55 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 6/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KHK | P50053 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14483300 | 0.88 | MEN1 (0.61) | PDE4DMEN1KMT2AALDH1A1CYP2C9 | |
| SCHEMBL2559503 | 0.87 | PDE4D (0.56) | PDE4DMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL12264899 | 0.83 | PDE4D (0.59) | PDE4DMEN1KMT2AALDH1A1CYP2C9 | |
| SCHEMBL14067435 | 0.78 | PDE4D (0.47) | PDE4DMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL2559747 | 0.78 | MEN1 (0.78) | PDE4DABCB1MEN1KMT2AALDH1A1 | |
| SCHEMBL23399943 | 0.76 | KDM4C (0.55) | PDE4DMEN1KMT2AALDH1A1MAPK1 | |
| SCHEMBL14482912 | 0.75 | MEN1 (0.47) | PDE4DMEN1KMT2AALDH1A1NPSR1 | |
| SCHEMBL4524302 | 0.75 | GAA (0.57) | PDE4DMEN1KMT2AALDH1A1CYP2C9 | |
| SCHEMBL2545006 | 0.73 | GAA (0.56) | PDE4DMEN1KMT2AALDH1A1CYP2C9 | |
| SCHEMBL12266477 | 0.73 | ALDH1A1 (0.49) | PDE4DMEN1KMT2AALDH1A1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2552895-B1 | PYRAZOLE SYNTHESIS BY COUPLING OF CARBOXYLIC ACID DERIVATIVES AND ENAMINES | Westfälische Wilhelms Universität Münster (DE) | 2015-02-25 | — | — | EP | disclosed |
| EP-2552895-B1 | PYRAZOLE SYNTHESIS BY COUPLING OF CARBOXYLIC ACID DERIVATIVES AND ENAMINES | Westfälische Wilhelms Universität Münster (DE) | 2015-02-25 | — | — | EP | disclosed |
| US-8716485-B2 | Pyrazole synthesis by coupling of carboxylic acid derivatives and enamines | WESTFÄLISHE WILHELMS-UNIVERSITÄT MÜNSTER (DE) | 2014-05-06 | — | — | US | disclosed |
| US-8716485-B2 | Pyrazole synthesis by coupling of carboxylic acid derivatives and enamines | WESTFÄLISHE WILHELMS-UNIVERSITÄT MÜNSTER (DE) | 2014-05-06 | — | — | US | disclosed |
| US-8716485-B2 | Pyrazole synthesis by coupling of carboxylic acid derivatives and enamines | WESTFÄLISHE WILHELMS-UNIVERSITÄT MÜNSTER (DE) | 2014-05-06 | — | — | US | disclosed |
| EP-2552895-A1 | PYRAZOLE SYNTHESIS BY COUPLING OF CARBOXYLIC ACID DERIVATIVES AND ENAMINES | Westfälische Wilhelms-Universität Münster (DE) | 2013-02-06 | — | — | EP | disclosed |
| US-20130012715-A1 | PYRAZOLE SYNTHESIS BY COUPLING OF CARBOXYLIC ACID DERIVATIVES AND ENAMINES | WESTFAELISCHE WILHELMS UNIVERSITAET MUENSTER (DE) | 2013-01-10 | — | — | US | disclosed |
| US-20130012715-A1 | PYRAZOLE SYNTHESIS BY COUPLING OF CARBOXYLIC ACID DERIVATIVES AND ENAMINES | WESTFAELISCHE WILHELMS UNIVERSITAET MUENSTER (DE) | 2013-01-10 | — | — | US | disclosed |
| US-20130012715-A1 | PYRAZOLE SYNTHESIS BY COUPLING OF CARBOXYLIC ACID DERIVATIVES AND ENAMINES | WESTFAELISCHE WILHELMS UNIVERSITAET MUENSTER (DE) | 2013-01-10 | — | — | US | disclosed |
| WO-2011120861-A1 | PYRAZOLE SYNTHESIS BY COUPLING OF CARBOXYLIC ACID DERIVATIVES AND ENAMINES | WESTFÄLISHE WILHELMS-UNIVERSITÄT MÜNSTER (DE) | 2011-10-06 | — | — | WO | disclosed |
| WO-2011120861-A1 | PYRAZOLE SYNTHESIS BY COUPLING OF CARBOXYLIC ACID DERIVATIVES AND ENAMINES | WESTFÄLISHE WILHELMS-UNIVERSITÄT MÜNSTER (DE) | 2011-10-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130012715-A1 | PYRAZOLE SYNTHESIS BY COUPLING OF CARBOXYLIC ACID DERIVATIVES AND ENAMINES | PC, ENO1, PDK2 | PDE4D 2593/4885ABCB1 3290/4885MEN1 2319/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.