Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 14/20 | 0.67 |
| ▸ | HRH1 | P35367 | 15/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | HTR1E | P28566 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4138331 | 0.92 | HTR6 (0.59) | HTR6HRH1PTGDR2 | |
| SCHEMBL14067941 | 0.90 | HRH1 (0.66) | HTR6HRH1GRIN2B | |
| SCHEMBL14067948 | 0.88 | HRH1 (0.63) | HTR6HRH1GRIN2BADRA2ADRD2 | |
| SCHEMBL14067785 | 0.83 | HRH1 (0.59) | HTR6HRH1PTGDR2GRIN2B | |
| SCHEMBL14067795 | 0.83 | HRH1 (0.64) | HTR6HRH1PTGDR2GRIN2B | |
| SCHEMBL14067793 | 0.82 | HRH1 (0.65) | HTR6HRH1SIGMAR1PTGDR2GRIN2B | |
| SCHEMBL14067790 | 0.82 | HTR6 (0.62) | HTR6HRH1PTGDR2GRIN2BADRA2A | |
| SCHEMBL4132463 | 0.81 | HTR6 (1.00) | HTR6HRH1SIGMAR1GRIN2BADRA2A | |
| SCHEMBL14067792 | 0.81 | HRH1 (0.61) | HTR6HRH1PTGDR2HTR5A | |
| SCHEMBL14067657 | 0.81 | HRH1 (0.56) | HTR6HRH1GRIN2BBCHEGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008115098-A2 | SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLES, METHODS FOR THE PRODUCTION AND THE USE THEREOF | ALLA CHEM, LLC (US) | 2008-09-25 | — | — | WO | disclosed |