Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 4/20 | 0.56 |
| ▸ | HTR6 | P50406 | 3/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 9/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.47 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.47 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14067948 | 0.92 | HRH1 (0.63) | HRH1HTR6HDAC6HDAC1MEN1 | |
| SCHEMBL14067785 | 0.89 | HRH1 (0.59) | HRH1HTR6GRIN2B | |
| SCHEMBL14067979 | 0.84 | HDAC6 (0.61) | HRH1HTR6HDAC6HDAC1HDAC10 | |
| SCHEMBL14067792 | 0.84 | HRH1 (0.61) | HRH1HTR6HDAC6HDAC1MEN1 | |
| SCHEMBL14067941 | 0.82 | HRH1 (0.66) | HRH1HTR6GRIN2B | |
| SCHEMBL4138331 | 0.81 | HTR6 (0.59) | HRH1HTR6HDAC6HDAC1MEN1 | |
| SCHEMBL8034952 | 0.81 | HDAC6 (0.57) | HRH1HTR6HDAC6HDAC1HDAC10 | |
| SCHEMBL14067945 | 0.81 | HTR6 (0.67) | HRH1HTR6BCHEGRIN1GRIN2A | |
| SCHEMBL4132976 | 0.80 | HRH1 (0.56) | HRH1HTR6HDAC6HDAC1MEN1 | |
| SCHEMBL3718005 | 0.80 | MAOA (0.62) | HRH1HTR6HDAC6HDAC1HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008115098-A2 | SUBSTITUTED 2,3,4,5-TETRAHYDRO-1H-PYRIDO[4,3-B]INDOLES, METHODS FOR THE PRODUCTION AND THE USE THEREOF | ALLA CHEM, LLC (US) | 2008-09-25 | — | — | WO | disclosed |