Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.40 |
| ▸ | MLYCD | O95822 | 1/20 | 0.40 |
| ▸ | EIF2S1 | P05198 | 2/20 | 0.39 |
| ▸ | EIF2AK3 | Q9NZJ5 | 2/20 | 0.39 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.38 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.38 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.38 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.38 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.38 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.38 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.38 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.38 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.38 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.38 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.38 |
| ▸ | PSMB6 | P28072 | 1/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | PSMB10 | P40306 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL4762160 | 0.98 | ALOX5 (0.43) | ALOX5ALDH1A1ANO1MLYCDEIF2S1 | |
| SCHEMBL1503262 | 0.83 | GAA (0.43) | ALDH1A1GAAHPGDKEAP1 | |
| Hydrochloric Acid SCHEMBL3840135 | 0.81 | GAA (0.42) | ALDH1A1GAAHPGDKEAP1 | |
| Hydrochloric Acid SCHEMBL4763208 | 0.81 | GAA (0.42) | ALDH1A1GAAHPGDKEAP1 | |
| SCHEMBL14067872 | 0.80 | HDAC4 (0.41) | PSMB11PSMA7PSMB1PSMA1PSMA2 | |
| SCHEMBL2076694 | 0.80 | SLC6A4 (0.44) | ALDH1A1GAAHPGDKEAP1 | |
| SCHEMBL7137660 | 0.79 | CES2 (0.55) | ALOX5ALDH1A1ANO1PSMB11PSMA7 | |
| Hydrochloric Acid SCHEMBL4767213 | 0.79 | HDAC4 (0.40) | EIF2S1EIF2AK3PSMB11PSMA7PSMB1 | |
| SCHEMBL6755715 | 0.79 | MAPK8 (0.44) | KEAP1 | |
| Hydrochloric Acid SCHEMBL1977404 | 0.78 | SLC6A4 (0.43) | ALDH1A1GAAHPGDKEAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1496836-B1 | N-(SUBSTITUTED BENZYL)-8-HYDROXY-1,6-NAPHTHYRIDINE-7- CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO INC (US) | 2008-09-24 | — | — | EP | disclosed |
| US-7323460-B2 | N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides useful as HIV integrase inhibitors | MERCK & CO., INC. (US) | 2008-01-29 | — | — | US | disclosed |
| US-7323460-B2 | N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7-carboxamides useful as HIV integrase inhibitors | MERCK & CO., INC. (US) | 2008-01-29 | — | — | US | disclosed |