Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC1 | P48995 | 1/20 | 0.45 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.45 |
| ▸ | STIM1 | Q13586 | 1/20 | 0.45 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.45 |
| ▸ | STIM2 | Q9P246 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.43 |
| ▸ | HPGD | P15428 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1406984 | 0.94 | TRPC1 (0.49) | TRPC1TRPC3STIM1ORAI1STIM2 | |
| SCHEMBL1407027 | 0.89 | TRPC1 (0.46) | TRPC1TRPC3STIM1ORAI1STIM2 | |
| SCHEMBL1406945 | 0.89 | TRPC1 (0.46) | TRPC1TRPC3STIM1ORAI1STIM2 | |
| SCHEMBL1406944 | 0.89 | TRPC1 (0.46) | TRPC1TRPC3STIM1ORAI1STIM2 | |
| SCHEMBL1407189 | 0.89 | TRPC1 (0.47) | TRPC1TRPC3STIM1ORAI1STIM2 | |
| SCHEMBL1407035 | 0.89 | LMNA (0.48) | TRPC1TRPC3STIM1ORAI1STIM2 | |
| SCHEMBL1407011 | 0.88 | LMNA (0.50) | TRPC1TRPC3STIM1ORAI1STIM2 | |
| SCHEMBL4719065 | 0.85 | LMNA (0.45) | TRPC1TRPC3STIM1ORAI1STIM2 | |
| SCHEMBL4718208 | 0.84 | LMNA (0.47) | TRPC1TRPC3STIM1ORAI1STIM2 | |
| Hydrochloric Acid SCHEMBL4720818 | 0.81 | LMNA (0.44) | TRPC1TRPC3STIM1ORAI1STIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295411-A1 | Pyrazoles as 11-beta-hsd-1 | F. Hoffmann-La Roche AG (CH) | 2011-03-16 | — | — | EP | disclosed |