Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 5/20 | 0.55 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | KIT | P10721 | 1/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.51 |
| ▸ | BRAF | P15056 | 8/20 | 0.48 |
| ▸ | LCK | P06239 | 4/20 | 0.48 |
| ▸ | KDR | P35968 | 4/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.48 |
| ▸ | ESYT2 | A0FGR8 | 1/20 | 0.48 |
| ▸ | PLEKHG3 | A1L390 | 1/20 | 0.48 |
| ▸ | NBAS | A2RRP1 | 1/20 | 0.48 |
| ▸ | CNOT1 | A5YKK6 | 1/20 | 0.48 |
| ▸ | TBKBP1 | A7MCY6 | 1/20 | 0.48 |
| ▸ | MYO1G | B0I1T2 | 1/20 | 0.48 |
| ▸ | AGPS | O00116 | 1/20 | 0.48 |
| ▸ | MYO1F | O00160 | 1/20 | 0.48 |
| ▸ | SNAP23 | O00161 | 1/20 | 0.48 |
| ▸ | AP3B1 | O00203 | 1/20 | 0.48 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.48 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14069588 | 0.89 | BTK (0.67) | BTKCSF1RKITBRAFLCK | |
| SCHEMBL4786461 | 0.87 | BRAF (0.62) | BTKCSF1RBRAFLCKKDR | |
| SCHEMBL14069583 | 0.86 | CSF1R (0.58) | BTKCSF1RKITBRAFLCK | |
| SCHEMBL14069854 | 0.86 | CSF1R (0.59) | BTKCSF1RBRAFLCKKDR | |
| SCHEMBL14069584 | 0.85 | LYN (0.59) | BTKCSF1RBRAFLCKKDR | |
| SCHEMBL14069589 | 0.84 | BRAF (0.54) | BTKCSF1RBRAFLCKKDR | |
| SCHEMBL14070062 | 0.84 | BTK (0.54) | BTKCSF1RKITBRAFLCK | |
| SCHEMBL14070274 | 0.83 | BRAF (0.57) | BTKCSF1RBRAFRAF1 | |
| SCHEMBL14070059 | 0.82 | BTK (0.49) | BTKCSF1RKITBRAFLCK | |
| SCHEMBL14070272 | 0.81 | BTK (0.54) | BTKCSF1RKITBRAFLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008112695-A2 | PYRAZOLO [3,4-D] PYRIMIDINES AND 1, 2, 5, 6-TETRAAZA- AS- INDACENES AS PROTEIN KINASE INHIBITORS FOR CANCER TREATMENT | IRM LLC (BM) | 2008-09-18 | — | — | WO | disclosed |