Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | CSF1R | P07333 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.54 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.54 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.53 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 7/20 | 0.51 |
| ▸ | BRAF | P15056 | 5/20 | 0.51 |
| ▸ | BCR | P11274 | 3/20 | 0.51 |
| ▸ | SRC | P12931 | 3/20 | 0.51 |
| ▸ | LCK | P06239 | 2/20 | 0.51 |
| ▸ | FYN | P06241 | 2/20 | 0.51 |
| ▸ | YES1 | P07947 | 2/20 | 0.51 |
| ▸ | LYN | P07948 | 2/20 | 0.51 |
| ▸ | HCK | P08631 | 2/20 | 0.51 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.51 |
| ▸ | FRK | P42685 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14069756 | 0.87 | BRAF (0.60) | CSF1RMAPK14MAP4K2MAP3K7ABL1 | |
| SCHEMBL14069754 | 0.85 | PIKFYVE (0.60) | CSF1RPOLBBRAFKDRKIT | |
| SCHEMBL14069583 | 0.84 | CSF1R (0.58) | MAPTCSF1RKDM4EPOLBRECQL | |
| SCHEMBL4788935 | 0.82 | CSF1R (0.63) | MAPTCSF1RKDM4EPOLBRECQL | |
| SCHEMBL4787141 | 0.81 | CSF1R (0.67) | MAPTCSF1RKDM4EPOLBRECQL | |
| SCHEMBL4788638 | 0.81 | CSF1R (0.69) | MAPTCSF1RKDM4EPOLBRECQL | |
| SCHEMBL13708168 | 0.80 | CSF1R (0.61) | MAPTCSF1RKDM4EPOLBRECQL | |
| SCHEMBL15381989 | 0.79 | CSF1R (0.71) | MAPTCSF1RKDM4EPOLBRECQL | |
| SCHEMBL4587496 | 0.79 | CSF1R (0.56) | MAPTCSF1RKDM4EPOLBRECQL | |
| SCHEMBL3388334 | 0.79 | CSF1R (0.60) | MAPTCSF1RKDM4EPOLBRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008112695-A2 | PYRAZOLO [3,4-D] PYRIMIDINES AND 1, 2, 5, 6-TETRAAZA- AS- INDACENES AS PROTEIN KINASE INHIBITORS FOR CANCER TREATMENT | IRM LLC (BM) | 2008-09-18 | — | — | WO | disclosed |