Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSF1R | P07333 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | RECQL | P46063 | 1/20 | 0.64 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.62 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.62 |
| ▸ | RAF1 | P04049 | 3/20 | 0.60 |
| ▸ | NR2E1 | Q9Y466 | 5/20 | 0.57 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
| ▸ | MAP3K20 | Q9NYL2 | 1/20 | 0.53 |
| ▸ | BRAF | P15056 | 3/20 | 0.51 |
| ▸ | ABL1 | P00519 | 3/20 | 0.51 |
| ▸ | HCK | P08631 | 2/20 | 0.51 |
| ▸ | BCR | P11274 | 2/20 | 0.51 |
| ▸ | NR2C2 | P49116 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4787135 | 0.90 | MAP3K7 (0.61) | CSF1RMAPTKDM4EPOLBRECQL | |
| SCHEMBL4788935 | 0.88 | CSF1R (0.63) | CSF1RMAPTKDM4EPOLBRECQL | |
| SCHEMBL4788638 | 0.84 | CSF1R (0.69) | CSF1RMAPTKDM4EPOLBRECQL | |
| SCHEMBL13708168 | 0.83 | CSF1R (0.61) | CSF1RMAPTKDM4EPOLBRECQL | |
| SCHEMBL3388334 | 0.83 | CSF1R (0.60) | CSF1RMAPTKDM4EPOLBRECQL | |
| SCHEMBL4787643 | 0.83 | BRAF (0.70) | CSF1RRAF1MAPK14BRAFABL1 | |
| SCHEMBL19376837 | 0.82 | CSF1R (0.74) | CSF1RMAPTKDM4EPOLBRECQL | |
| SCHEMBL15556278 | 0.82 | EPHB2 (0.82) | CSF1RMAPTKDM4EPOLBRECQL | |
| SCHEMBL14069752 | 0.81 | MAPT (0.59) | CSF1RMAPTKDM4EPOLBRECQL | |
| SCHEMBL4587496 | 0.81 | CSF1R (0.56) | CSF1RMAPTKDM4EPOLBRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | claimed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |
| WO-2008144253-A1 | PROTEIN KINASE INHIBITORS AND METHODS FOR USING THEREOF | IRM LLC (BM) | 2008-11-27 | — | — | WO | disclosed |