Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 3/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 7/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.43 |
| ▸ | TLR8 | Q9NR97 | 4/20 | 0.41 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.41 |
| ▸ | TLR9 | Q9NR96 | 3/20 | 0.41 |
| ▸ | F9 | P00740 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 3/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | CCNC | P24863 | 1/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.38 |
| ▸ | SCD | O00767 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.37 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14072365 | 0.89 | MAP4K4 (0.52) | MAP4K4DYRK1APIK3CBTLR8TLR7 | |
| SCHEMBL14063602 | 0.81 | MAP4K4 (0.39) | MAP4K4DYRK1ATLR8TLR7TLR9 | |
| SCHEMBL12928152 | 0.75 | PIK3CA (0.59) | MAP4K4DYRK1APIK3CBCLK1 | |
| SCHEMBL15587569 | 0.74 | MAP4K4 (1.00) | MAP4K4 | |
| SCHEMBL29652381 | 0.73 | MAPT (0.50) | MAP4K4DYRK1AF9CDK8CDK9 | |
| SCHEMBL1759452 | 0.73 | MAPT (0.50) | MAP4K4DYRK1AF9CDK8CDK9 | |
| SCHEMBL29987075 | 0.73 | MAP4K4 (0.63) | MAP4K4DYRK1APIK3CBTLR8TLR7 | |
| SCHEMBL8276224 | 0.72 | MAP4K4 (0.42) | MAP4K4F9 | |
| SCHEMBL12441328 | 0.72 | F11 (0.46) | MAP4K4DYRK1APIK3CBTLR8TLR7 | |
| SCHEMBL1896511 | 0.72 | DYRK1A (0.65) | MAP4K4DYRK1APIK3CBCLK1CCNC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429604-B2 | Six-membered heterocycles useful as serine protease inhibitors | BRISTOL MYERS SQUIBB COMPANY (US) | 2008-09-30 | — | — | US | disclosed |