Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 3/20 | 0.39 |
| ▸ | F11 | P03951 | 3/20 | 0.38 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 3/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.34 |
| ▸ | F9 | P00740 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12441328 | 0.89 | F11 (0.46) | MAP4K4F11DYRK1AGSK3BTLR8 | |
| SCHEMBL14072483 | 0.81 | MAP4K4 (0.58) | MAP4K4DYRK1ATLR8TLR7TLR9 | |
| SCHEMBL14063598 | 0.73 | JAK2 (0.61) | MAP4K4F11DYRK1AGSK3BTGFBR1 | |
| SCHEMBL7763399 | 0.72 | TBK1 (0.44) | F10 | |
| SCHEMBL12928152 | 0.72 | PIK3CA (0.59) | MAP4K4AKT1DYRK1A | |
| SCHEMBL14063586 | 0.72 | DYRK1A (0.51) | DYRK1AGSK3BTLR8TLR7TLR9 | |
| SCHEMBL14072365 | 0.71 | MAP4K4 (0.52) | MAP4K4F11DYRK1ATLR8TLR7 | |
| SCHEMBL8276223 | 0.70 | PDPK1 (0.65) | F11TGFBR1 | |
| SCHEMBL1483785 | 0.70 | RET (0.55) | — | |
| SCHEMBL14063540 | 0.68 | MAP4K4 (0.49) | MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429604-B2 | Six-membered heterocycles useful as serine protease inhibitors | BRISTOL MYERS SQUIBB COMPANY (US) | 2008-09-30 | — | — | US | disclosed |