Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.41 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.41 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.41 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.41 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.41 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 3/20 | 0.40 |
| ▸ | RARA | P10276 | 2/20 | 0.40 |
| ▸ | RARG | P13631 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | SREBF1 | P36956 | 1/20 | 0.39 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14072851 | 0.83 | KMT2A (0.60) | CDC7DBF4CYP3A4CYP2D6PSEN1 | |
| SCHEMBL14063619 | 0.77 | — | — | |
| SCHEMBL10272455 | 0.76 | TDO2 (0.50) | LMNACYP3A4CYP2D6PSEN1PSEN2 | |
| SCHEMBL31555358 | 0.76 | CYP1A2 (0.52) | CDC7DBF4CYP3A4CYP2D6PSEN1 | |
| SCHEMBL27516792 | 0.75 | CDC7 (0.46) | LMNACDC7DBF4SREBF1SREBF2 | |
| SCHEMBL14015421 | 0.75 | SREBF2 (0.50) | CDC7DBF4CYP3A4CYP2D6PSEN1 | |
| SCHEMBL15580692 | 0.74 | SCN9A (0.47) | LMNAMCL1RARBRARARARG | |
| SCHEMBL18304669 | 0.73 | STING1 (0.47) | — | |
| SCHEMBL20462871 | 0.72 | KAT6A (0.58) | — | |
| SCHEMBL13273291 | 0.72 | SREBF2 (0.50) | LMNACDC7DBF4CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429604-B2 | Six-membered heterocycles useful as serine protease inhibitors | BRISTOL MYERS SQUIBB COMPANY (US) | 2008-09-30 | — | — | US | disclosed |