Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 4/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13927630 | 0.86 | ADORA1 (0.40) | ADORA2AADORA1DPP4ADORA2BKDM4E | |
| SCHEMBL13854650 | 0.83 | MAPK14 (0.47) | ADORA2AADORA1DPP4ADORA2BKDM4E | |
| SCHEMBL14074984 | 0.80 | SRC (0.51) | ADORA2AADORA1KDM4EMAPTALDH1A1 | |
| SCHEMBL13927629 | 0.78 | ALDH1A1 (0.45) | KDM4EALDH1A1MAPK14USP2CYP1A2 | |
| SCHEMBL13927632 | 0.78 | PTGER1 (0.39) | ADORA2AADORA1ADORA2BKDM4EMAPT | |
| SCHEMBL4137268 | 0.78 | DPP4 (0.42) | ADORA2AADORA1DPP4ADORA2BKDM4E | |
| SCHEMBL14075010 | 0.77 | TRPA1 (0.36) | KDM4EMAPTALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL14075013 | 0.75 | CLK2 (0.37) | ADORA1MEN1MAPTKMT2AMAP4K4 | |
| SCHEMBL31632811 | 0.74 | ADORA2A (0.42) | ADORA2AADORA1DPP4ADORA2BKDM4E | |
| SCHEMBL23557987 | 0.73 | ADORA2A (0.49) | ADORA2AADORA1DPP4ADORA2BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429609-B2 | Pyrazole compound and medicinal composition containing the same | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-09-30 | — | — | US | disclosed |