Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 7/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.49 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14087834 | 0.94 | METAP2 (0.70) | METAP2CYP2C9CYP1A2LMNAHTT | |
| SCHEMBL13034766 | 0.88 | METAP2 (0.62) | METAP2CYP2C9CYP1A2LMNAHTT | |
| SCHEMBL13034755 | 0.87 | METAP2 (0.61) | METAP2CYP2C9CYP1A2LMNAHTT | |
| SCHEMBL13034757 | 0.86 | METAP2 (0.60) | METAP2CYP2C9CYP1A2LMNAHTT | |
| SCHEMBL3980105 | 0.85 | METAP2 (0.81) | METAP2CYP2C9CYP1A2LMNAHTT | |
| SCHEMBL12570805 | 0.82 | METAP2 (0.86) | METAP2CYP2C9CYP1A2LMNAHTT | |
| SCHEMBL13034754 | 0.81 | FFAR4 (0.60) | METAP2CYP2C9CYP1A2LMNAHTT | |
| SCHEMBL13034736 | 0.80 | METAP2 (0.53) | METAP2CYP2C9CYP1A2LMNAHTT | |
| SCHEMBL16496289 | 0.79 | METAP2 (0.75) | METAP2CYP2C9CYP1A2LMNAHTT | |
| SCHEMBL5181886 | 0.77 | HSD17B2 (0.78) | METAP2CYP2C9HSD17B2LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429677-B2 | Small molecule entry inhibitors | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2008-09-30 | — | — | US | disclosed |