Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 20/20 | 0.57 |
| ▸ | MMP14 | P50281 | 8/20 | 0.57 |
| ▸ | MMP12 | P39900 | 5/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL941781 | 0.89 | MMP13 (0.67) | MMP13MMP14MMP12KCNH2 | |
| SCHEMBL5035908 | 0.85 | MMP13 (0.56) | MMP13MMP14MMP12KCNH2 | |
| SCHEMBL5035910 | 0.85 | MMP13 (0.56) | MMP13MMP14MMP12KCNH2 | |
| SCHEMBL942608 | 0.84 | MMP13 (0.55) | MMP13MMP14MMP12 | |
| SCHEMBL941507 | 0.80 | MMP13 (0.64) | MMP13MMP14MMP12 | |
| SCHEMBL941464 | 0.79 | MMP13 (0.81) | MMP13MMP14MMP12KCNH2 | |
| SCHEMBL12911650 | 0.76 | MMP13 (0.63) | MMP13MMP14MMP12KCNH2 | |
| SCHEMBL943181 | 0.76 | MMP13 (0.60) | MMP13MMP14MMP12KCNH2 | |
| SCHEMBL942583 | 0.74 | MMP13 (0.58) | MMP13MMP14MMP12KCNH2 | |
| SCHEMBL941035 | 0.74 | MMP13 (0.63) | MMP13MMP14MMP12KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7427631-B2 | especially as inhibitors of MMP12 | ASTRAZENECA AB (SE) | 2008-09-23 | — | — | US | disclosed |
| US-7427631-B2 | especially as inhibitors of MMP12 | ASTRAZENECA AB (SE) | 2008-09-23 | — | — | US | disclosed |