Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 19/20 | 0.56 |
| ▸ | MMP12 | P39900 | 5/20 | 0.56 |
| ▸ | MMP14 | P50281 | 8/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5035910 | 1.00 | MMP13 (0.56) | MMP13MMP12MMP14KDM4EKCNH2 | |
| SCHEMBL14075992 | 0.85 | MMP13 (0.57) | MMP13MMP12MMP14KCNH2 | |
| SCHEMBL941781 | 0.81 | MMP13 (0.67) | MMP13MMP12MMP14KCNH2 | |
| SCHEMBL12911560 | 0.80 | MMP13 (0.56) | MMP13MMP12MMP14KCNH2 | |
| SCHEMBL942622 | 0.79 | MMP13 (0.55) | MMP13MMP12MMP14KCNH2 | |
| SCHEMBL12911553 | 0.79 | MMP13 (0.55) | MMP13MMP12MMP14KCNH2 | |
| SCHEMBL14075991 | 0.79 | MMP13 (0.59) | MMP13MMP12MMP14 | |
| SCHEMBL12911650 | 0.79 | MMP13 (0.63) | MMP13MMP12MMP14KCNH2 | |
| Trifluoroacetic Acid SCHEMBL941177 | 0.78 | MMP13 (0.52) | MMP13MMP12MMP14KCNH2 | |
| SCHEMBL942609 | 0.78 | MMP13 (0.55) | MMP13MMP12MMP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7427631-B2 | especially as inhibitors of MMP12 | ASTRAZENECA AB (SE) | 2008-09-23 | — | — | US | disclosed |
| EP-1370556-B1 | METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2006-07-19 | — | — | EP | disclosed |
| EP-1676846-A2 | Hydantoin derivatives as MMP inhibitors | AstraZeneca AB (SE) | 2006-07-05 | — | — | EP | disclosed |
| US-20040147573-A1 | Metalloproteinase inhibitors | ASTRAZENECA AB (SE) | 2004-07-29 | — | — | US | disclosed |
| US-20040127528-A1 | Metalloproteinase inhibitors | ASTRAZENECA AB (SE) | 2004-07-01 | — | — | US | disclosed |
| EP-1370536-A1 | METALLOPROTEINASE INHIBITORS | AstraZeneca AB (SE) | 2003-12-17 | — | — | EP | disclosed |
| WO-2002074750-A1 | METALLOPROTEINASE INHIBITORS | ASTRAZENECA AB (SE) | 2002-09-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127528-A1 | Metalloproteinase inhibitors | MMP9, MMP10, MMP3 | MMP13 10/4885MMP12 5/4885MMP14 6/4885 |
| US-20040147573-A1 | Metalloproteinase inhibitors | MMP12, MMP7, MMP10 | MMP13 19/4885MMP12 1/4885MMP14 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.