SCHEMBL14076582

SCHEMBL14076582

Cc1ccc(C2/C(=N/C(C)(C)CC(C)(C)C)NC(=O)N2c2ccc3nc[nH]c3c2)c(C)c1

nearest known ligand 0.53

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ QPCT Q16769 20/20 0.53
▸ QPCTL Q9NXS2 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5063722 1.00 QPCT (0.53) QPCTQPCTL
SCHEMBL14076694 0.90 QPCT (0.45) QPCTQPCTL
SCHEMBL5053534 0.90 QPCT (0.45) QPCTQPCTL
SCHEMBL5053557 0.88 QPCT (0.54) QPCTQPCTL
SCHEMBL14076620 0.88 QPCT (0.54) QPCTQPCTL
SCHEMBL5061942 0.80 QPCT (0.54) QPCTQPCTL
SCHEMBL5061946 0.80 QPCT (0.54) QPCTQPCTL
SCHEMBL14076608 0.80 QPCT (0.54) QPCTQPCTL
SCHEMBL14076356 0.79 QPCT (0.46) QPCTQPCTL
SCHEMBL5058073 0.79 QPCT (0.46) QPCTQPCTL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2091945-B1 NOVEL INHIBITORS OF GLUTAMINYL CYCLASE PROBIODRUG AG (DE) 2014-01-15 — — EP disclosed
US-20080221086-A1 Novel Inhibitors of Glutaminyl Cyclase PROBIODRUG AG (DE) 2008-09-11 — — US disclosed
US-20080221086-A1 Novel Inhibitors of Glutaminyl Cyclase PROBIODRUG AG (DE) 2008-09-11 — — US disclosed
WO-2008055947-A1 NOVEL INHIBITORS OF GLUTAMINYL CYCLASE PROBIODRUG AG (DE) 2008-05-15 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080221086-A1 Novel Inhibitors of Glutaminyl Cyclase GLS, GLS2, GLUL QPCT 9/4885QPCTL 57/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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