Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | SCN4A | P35499 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.33 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3299636 | 0.77 | ALDH1A1 (0.47) | ALDH1A1MAPTCACNA1FCYP2C9HTR2A | |
| SCHEMBL14258078 | 0.73 | CYP2C19 (0.45) | ALDH1A1MAPTUSP2GAALMNA | |
| SCHEMBL8090986 | 0.69 | ALDH1A1 (0.40) | ALDH1A1MAPTMMP2MMP9GAA | |
| SCHEMBL7236829 | 0.67 | ALDH1A1 (0.45) | ALDH1A1MAPTCACNA1FCYP2C9HTR2A | |
| SCHEMBL7977554 | 0.67 | ALDH1A1 (0.45) | ALDH1A1MAPTCACNA1FCYP2C9HTR2A | |
| SCHEMBL2086656 | 0.65 | ALDH1A1 (0.40) | ALDH1A1MMP2MMP9GAALMNA | |
| SCHEMBL14077810 | 0.64 | BACE1 (0.46) | ALDH1A1MMP2MMP9HTTBACE1 | |
| SCHEMBL7480064 | 0.63 | CNR1 (0.44) | ALDH1A1MAPTCYP2C9GAALMNA | |
| SCHEMBL9717767 | 0.63 | ALDH1A1 (0.37) | ALDH1A1MAPTCACNA1FCYP2C9HTR2A | |
| SCHEMBL7488088 | 0.63 | CYP2C9 (0.42) | ALDH1A1MAPTCACNA1FCYP2C9HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214577-A1 | New Compounds 320 | ASTRAZENECA AB (SE) | 2008-09-04 | — | — | US | disclosed |
| US-20080058349-A1 | New Compounds 318 | ASTRAZENECA AB (SE) | 2008-03-06 | — | — | US | disclosed |
| US-20070299087-A1 | New Compounds 319 | ASTRAZENECA AB (SE) | 2007-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299087-A1 | New Compounds 319 | PSEN2, PSEN1, MAPT | ALDH1A1 2495/4885MAPT 3/4885CACNA1F 297/4885 |
| US-20080214577-A1 | New Compounds 320 | PSEN1, PSEN2, MAPT | ALDH1A1 2575/4885MAPT 3/4885CACNA1F 243/4885 |
| US-20080058349-A1 | New Compounds 318 | PSEN2, PSEN1, MAPT | ALDH1A1 2566/4885MAPT 3/4885CACNA1F 326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.