Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP9 | P14780 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | NAT1 | P18440 | 1/20 | 0.32 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7236829 | 0.81 | ALDH1A1 (0.45) | ALDH1A1MMP2MMP9GAACA2 | |
| SCHEMBL7977554 | 0.81 | ALDH1A1 (0.45) | ALDH1A1MMP2MMP9GAACA2 | |
| SCHEMBL14077803 | 0.69 | ALDH1A1 (0.40) | ALDH1A1MMP2MMP9GAAHTT | |
| SCHEMBL3299636 | 0.65 | ALDH1A1 (0.47) | ALDH1A1MMP2MMP9GAABACE1 | |
| SCHEMBL7243423 | 0.63 | CYP2C19 (0.50) | LMNATSHR | |
| SCHEMBL7480064 | 0.63 | CNR1 (0.44) | ALDH1A1GAALMNAKDM4EMAPT | |
| SCHEMBL4237258 | 0.62 | ALDH1A1 (0.56) | ALDH1A1MMP2MMP9GAAHTT | |
| SCHEMBL542865 | 0.60 | ALDH1A1 (0.59) | ALDH1A1MMP2MMP9LMNAMAPT | |
| SCHEMBL4384462 | 0.60 | ALDH1A1 (0.59) | ALDH1A1MMP2MMP9LMNAMAPT | |
| SCHEMBL16705613 | 0.60 | ALDH1A1 (0.42) | ALDH1A1MMP2MMP9GAAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100168091-A1 | Imidazole Amines As Inhibitors Of Beta-secretase | WYETH LLC (US) | 2010-07-01 | — | — | US | disclosed |
| US-7700606-B2 | Imidazole amines as inhibitors of β-secretase | WYETH LLC (US) | 2010-04-20 | — | — | US | disclosed |
| US-20080214577-A1 | New Compounds 320 | ASTRAZENECA AB (SE) | 2008-09-04 | — | — | US | disclosed |
| US-20080051420-A1 | New Compounds 317 | ASTRAZENECA AB (SE) | 2008-02-28 | — | — | US | disclosed |
| US-20080051390-A1 | Imidazole amines as inhibitors of beta-secretase | WYETH (US) | 2008-02-28 | — | — | US | disclosed |
| US-20070299087-A1 | New Compounds 319 | ASTRAZENECA AB (SE) | 2007-12-27 | — | — | US | disclosed |
| EP-0713132-B1 | Chemical sensitisation of silver halide emulsions | EASTMAN KODAK CO (US) | 2000-12-20 | — | — | EP | disclosed |
| US-5604084-A | ADDING SULFUR RELEASING ORGANIC POLYMER HAVING MULTIPLE SULFUR RELEASING GROUPS | IMATION CORP. (US) | 1997-02-18 | — | — | US | disclosed |
| EP-0713132-A1 | Chemical sensitisation of silver halide emulsions | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1996-05-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070299087-A1 | New Compounds 319 | PSEN2, PSEN1, MAPT | ALDH1A1 2495/4885MMP2 2473/4885MMP9 2504/4885 |
| US-20100168091-A1 | Imidazole Amines As Inhibitors Of Beta-secretase | BACE1, BACE2, APP | ALDH1A1 945/4885MMP2 805/4885MMP9 927/4885 |
| US-20080214577-A1 | New Compounds 320 | PSEN1, PSEN2, MAPT | ALDH1A1 2575/4885MMP2 2898/4885MMP9 3049/4885 |
| US-20080051420-A1 | New Compounds 317 | PSEN2, PSEN1, MAPT | ALDH1A1 2455/4885MMP2 2723/4885MMP9 3172/4885 |
| US-20080051390-A1 | Imidazole amines as inhibitors of beta-secretase | BACE1, BACE2, APP | ALDH1A1 912/4885MMP2 588/4885MMP9 809/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.