Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 2/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
| ▸ | SMO | Q99835 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.39 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11943442 | 0.93 | ALDH1A1 (0.42) | NPC1RAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL14081533 | 0.92 | ALDH1A1 (0.46) | NPC1RAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL11943345 | 0.89 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL11943414 | 0.87 | NPC1 (0.40) | NPC1RAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL11943441 | 0.86 | ALDH1A1 (0.44) | KMT2ALMNADRD2MAPTHRH3 | |
| SCHEMBL11943451 | 0.85 | NPC1 (0.43) | NPC1RAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL11943427 | 0.85 | ALDH1A1 (0.52) | NPC1RAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL11943439 | 0.85 | MAPT (0.45) | NPC1RAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL11943822 | 0.84 | LMNA (0.52) | SMN1; SMN2LMNAPOLBDRD2DRD4 | |
| SCHEMBL11943332 | 0.84 | SMN1; SMN2 (0.41) | NPC1RAB9ASMN1; SMN2KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2586778-A2 | Pyridazinone derivatives useful as glucan synthase inhibitors | Merck Sharp & Dohme Corp. (US) | 2013-05-01 | — | — | EP | disclosed |
| WO-2008115381-A1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | SCHERING CORPORATION (US) | 2008-09-25 | — | — | WO | disclosed |
| WO-2008115385-A2 | PIPERAZINE-SUBSTITUTED PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | SCHERING CORPORATION (US) | 2008-09-25 | — | — | WO | disclosed |