Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA3 | P07451 | 1/20 | 0.42 |
| ▸ | CA4 | P22748 | 1/20 | 0.42 |
| ▸ | CA6 | P23280 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.42 |
| ▸ | CA7 | P43166 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 5/20 | 0.34 |
| ▸ | ABAT | P80404 | 1/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3931441 | 0.69 | NOS1 (0.56) | GAAPKMCA12CA1CA2 | |
| SCHEMBL8186885 | 0.66 | NOS1 (0.56) | GAAPKMCA12CA1CA2 | |
| SCHEMBL879568 | 0.62 | AHR (0.50) | GAAPKMCA12CA1CA2 | |
| SCHEMBL1763460 | 0.62 | GAA (0.96) | GAAPKMMEN1KMT2AKDM4E | |
| SCHEMBL29361377 | 0.62 | AHR (0.50) | GAAPKMCA12CA1CA2 | |
| SCHEMBL111709 | 0.62 | CA2 (0.55) | CA12CA1CA2CA3CA4 | |
| SCHEMBL31164857 | 0.62 | CA2 (0.55) | CA12CA1CA2CA3CA4 | |
| SCHEMBL507041 | 0.62 | HTR1B (0.53) | CA12CA1CA2CA3CA4 | |
| SCHEMBL15828 | 0.61 | HRH3 (0.79) | CA12CA1CA2CA4CA6 | |
| Hydrochloric Acid SCHEMBL23704179 | 0.61 | AHR (0.48) | GAAPKMCA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2586778-A2 | Pyridazinone derivatives useful as glucan synthase inhibitors | Merck Sharp & Dohme Corp. (US) | 2013-05-01 | — | — | EP | disclosed |
| WO-2008115381-A1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | SCHERING CORPORATION (US) | 2008-09-25 | — | — | WO | disclosed |