Known targets — ChEMBL curated mechanism
823298382338688239847Rdl1Rdl2Rdl3
The experimentally established mechanism targets of Alpha-Hexachlorocyclohexane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | GABRA1 | P14867 | 1/20 | 1.00 |
| ▸ | GABRB1 | P18505 | 1/20 | 1.00 |
| ▸ | GABRG2 | P18507 | 1/20 | 1.00 |
| ▸ | GABRR1 | P24046 | 1/20 | 1.00 |
| ▸ | GABRB3 | P28472 | 1/20 | 1.00 |
| ▸ | GABRA6 | Q16445 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lindane SCHEMBL8575655 | 1.00 | LMNA (1.00) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL10795898 | 1.00 | LMNA (1.00) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL25895 | 1.00 | LMNA (1.00) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL9120917 | 1.00 | LMNA (1.00) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL75689 | 1.00 | LMNA (1.00) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL472088 | 1.00 | LMNA (1.00) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| SCHEMBL8406626 | 1.00 | LMNA (1.00) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL8110265 | 1.00 | LMNA (1.00) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL9242537 | 1.00 | LMNA (1.00) | LMNACYP3A4GABRA1GABRB1GABRG2 | |
| Lindane SCHEMBL140812 | 1.00 | LMNA (1.00) | LMNACYP3A4GABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 157 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250346506-A1 | Membrane-Mediated Electro-Oxidation-Reduction Deep Water Treatment Device and its Operation Method Thereof | HARBIN INST TECHNOLOGY (CN) | 2025-11-13 | — | — | US | claimed |
| WO-2024146144-A1 | MEMBRANE-MEDIATED ELECTROOXIDATION-REDUCTION ADVANCED WATER TREATMENT DEVICE AND OPERATION METHOD THEREOF | 哈尔滨工业大学 | 2024-07-11 | — | — | WO | claimed |
| CN-118139701-A | Soil restoration device and method based on solar evaporation | 徐浩兰 | 2024-06-04 | — | — | CN | claimed |
| CN-116282634-A | Membrane-mediated conductive oxidation-reduction advanced water treatment device and operation method thereof | 哈尔滨工业大学 | 2023-06-23 | — | — | CN | claimed |
| CN-115372493-A | Method for detecting 24 pesticide residues in traditional Chinese medicine and application | 广东微谱检测技术有限公司 | 2022-11-22 | — | — | CN | claimed |
| WO-2022217312-A1 | APPARATUS AND PROCESS FOR SOLAR EVAPORATION-BASED SOIL REMEDIATION | UNIVERSITY OF SOUTH AUSTRALIA (AU) | 2022-10-20 | — | — | WO | claimed |
| CN-110988162-A | Method for detecting pesticide residue in milk | 李良浩 | 2020-04-10 | — | — | CN | claimed |
| US-20130105387-A1 | TREATMENT FOR DEPOLLUTING WATER CONTAMINATED BY MICRO POLLUTANTS AND/OR EMERGENT POLLUTANTS, NOTABLY BY ORGANOCHLORINATED COMPOUNDS | RHODIA OPERATIONS (FR) | 2013-05-02 | — | — | US | claimed |
| US-4853223-A | DIPPING USING AQUEOUS DISPERSION OF MICROENCAPSULATED PARASITICIDE | CIBA-GEIGY CORPORATION (US) | 1989-08-01 | — | — | US | claimed |
| US-20260021111-A1 | GANAXOLONE FOR USE IN TREATMENT OF STATUS EPILEPTICUS | IMMEDICA PHARMA US INC (US) | 2026-01-22 | — | — | US | disclosed |
| US-20250346506-A1 | Membrane-Mediated Electro-Oxidation-Reduction Deep Water Treatment Device and its Operation Method Thereof | HARBIN INST TECHNOLOGY (CN) | 2025-11-13 | — | — | US | disclosed |
| US-12246026-B2 | Ganaxolone for use in treatment of status epilepticus | MARINUS PHARMACEUTICALS, INC. (US) | 2025-03-11 | — | — | US | disclosed |
| WO-2024146144-A1 | MEMBRANE-MEDIATED ELECTROOXIDATION-REDUCTION ADVANCED WATER TREATMENT DEVICE AND OPERATION METHOD THEREOF | 哈尔滨工业大学 | 2024-07-11 | — | — | WO | disclosed |
| WO-2024141002-A1 | NON-NUCLEIC ACID TARGET DETECTION METHOD BASED ON SPLIT CAS PROTEIN AND USE THEREOF | 上海吐露港生物科技有限公司 | 2024-07-04 | — | — | WO | disclosed |
| US-4298615-A | INSECTICIDES, MITICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1981-11-03 | — | — | US | disclosed |
| US-4296108-A | PESTICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1981-10-20 | — | — | US | disclosed |
| US-4271171-A | INSECTICIDES, MITICIDES | BASF AKTIENGESELLSCHAFT (DE) | 1981-06-02 | — | — | US | disclosed |
| US-4268506-A | PESTICIDES | BASF AKTIENGESELLSCHAFT (US) | 1981-05-19 | — | — | US | disclosed |
| US-4240979-A | Aroylureas | BASF AKTIENGESELLSCHAFT (DE) | 1980-12-23 | — | — | US | disclosed |
| US-3977952-A | ULTRAVIOLET RADIATION, FORMING CARBON DIOXIDE | C. F. SPIESS & SOHN (DT) | 1976-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12246026-B2 | Ganaxolone for use in treatment of status epilepticus | CYP21A2, CYP17A1, HSD17B11 | LMNA 3480/4885CYP3A4 65/4885GABRA1 183/4885 |
| US-20260021111-A1 | GANAXOLONE FOR USE IN TREATMENT OF STATUS EPILEPTICUS | CYP4A11, CYP21A2, CYP17A1 | LMNA 2794/4885CYP3A4 18/4885GABRA1 453/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.