Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17057989 | 0.85 | SMN1; SMN2 (0.40) | NPC1RAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL17058087 | 0.85 | MCHR1 (0.34) | NPC1RAB9ASMN1; SMN2SCN9AKMT2A | |
| SCHEMBL17058328 | 0.84 | NPC1 (0.35) | NPC1RAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL17057964 | 0.83 | NPC1 (0.36) | NPC1RAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL17058333 | 0.83 | POLB (0.38) | NPC1RAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL17058057 | 0.83 | MAPT (0.41) | NPC1RAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL17058077 | 0.83 | NPC1 (0.38) | NPC1RAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL17058046 | 0.83 | NPC1 (0.38) | NPC1RAB9ASMN1; SMN2KMT2ALMNA | |
| SCHEMBL11944450 | 0.82 | MAPT (0.42) | SMN1; SMN2LMNAPOLBMAPT | |
| SCHEMBL14899776 | 0.82 | ADRA2C (0.48) | NPC1RAB9ASMN1; SMN2KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008115381-A1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | SCHERING CORPORATION (US) | 2008-09-25 | — | — | WO | disclosed |