Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.42 |
| ▸ | BRD9 | Q9H8M2 | 9/20 | 0.40 |
| ▸ | BRD4 | O60885 | 4/20 | 0.39 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | BRD7 | Q9NPI1 | 2/20 | 0.37 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | MELK | Q14680 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17058354 | 0.87 | MCHR1 (0.38) | ADRA2CKMT2ASMN1; SMN2POLBLMNA | |
| SCHEMBL14899736 | 0.87 | NCF1 (0.50) | KMT2ASMN1; SMN2POLBLMNAHRH4 | |
| SCHEMBL17057799 | 0.86 | SMN1; SMN2 (0.39) | KMT2ASMN1; SMN2MEN1GAAUSP2 | |
| SCHEMBL11944442 | 0.85 | CACNB4 (0.38) | ADRA2CKMT2ASMN1; SMN2POLBLMNA | |
| SCHEMBL17058087 | 0.85 | MCHR1 (0.34) | ADRA2CKMT2ASMN1; SMN2POLBLMNA | |
| SCHEMBL14081346 | 0.82 | NPC1 (0.32) | KMT2ASMN1; SMN2POLBLMNAMEN1 | |
| SCHEMBL11944450 | 0.82 | MAPT (0.42) | SMN1; SMN2POLBLMNAMAPTMAPK1 | |
| SCHEMBL14899753 | 0.79 | SMN1; SMN2 (0.48) | KMT2ASMN1; SMN2POLBLMNAMEN1 | |
| SCHEMBL14899749 | 0.79 | SMN1; SMN2 (0.45) | KMT2ASMN1; SMN2POLBLMNAHRH4 | |
| SCHEMBL14899737 | 0.77 | SMN1; SMN2 (0.46) | KMT2ASMN1; SMN2POLBLMNAHRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2586778-A2 | Pyridazinone derivatives useful as glucan synthase inhibitors | Merck Sharp & Dohme Corp. (US) | 2013-05-01 | — | — | EP | disclosed |