Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 18/20 | 1.00 |
| ▸ | MAOA | P21397 | 13/20 | 1.00 |
| ▸ | ACHE | P22303 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14081504 | 0.94 | MAOB (0.88) | MAOBMAOAACHE | |
| SCHEMBL31429939 | 0.90 | MAOB (1.00) | MAOBMAOA | |
| SCHEMBL27760024 | 0.83 | EGFR (0.74) | MAOBMAOAACHE | |
| SCHEMBL17454724 | 0.81 | MAOB (0.82) | MAOBMAOA | |
| SCHEMBL25138590 | 0.80 | EGFR (0.78) | MAOBMAOAACHE | |
| SCHEMBL8171059 | 0.80 | CA1 (0.73) | MAOBMAOA | |
| SCHEMBL9628765 | 0.77 | PRKCZ (0.77) | MAOBMAOA | |
| SCHEMBL11208392 | 0.77 | EGFR (0.74) | MAOBMAOA | |
| SCHEMBL7461031 | 0.77 | MAOB (0.73) | MAOBMAOA | |
| SCHEMBL7456837 | 0.77 | MAOB (0.73) | MAOBMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7414048-B2 | 4,5-dihydro-isoxazole derivatives and their pharmaceutical use | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-08-19 | — | — | US | disclosed |
| US-7414048-B2 | 4,5-dihydro-isoxazole derivatives and their pharmaceutical use | JANSSEN PHARMACEUTICA, N.V. (BE) | 2008-08-19 | — | — | US | disclosed |