Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | GPR84 | Q9NQS5 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | SCN1A | P35498 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11553030 | 0.85 | KMT2A (0.45) | KMT2AMEN1L3MBTL1ALDH1A1ABL1 | |
| SCHEMBL11554607 | 0.85 | KMT2A (0.45) | KMT2AMEN1L3MBTL1ALDH1A1ABL1 | |
| SCHEMBL4862698 | 0.83 | GLA (0.57) | KMT2AMEN1L3MBTL1ALDH1A1ABL1 | |
| SCHEMBL14081917 | 0.81 | L3MBTL1 (0.46) | KMT2AL3MBTL1ALDH1A1MAPK1HIF1A | |
| SCHEMBL14107746 | 0.80 | LMNA (0.60) | KMT2AMEN1L3MBTL1ALDH1A1ABL1 | |
| SCHEMBL14081941 | 0.80 | MEN1 (0.56) | KMT2AMEN1L3MBTL1ALDH1A1ABL1 | |
| SCHEMBL2818943 | 0.77 | ABL1 (0.67) | KMT2AMEN1L3MBTL1ALDH1A1ABL1 | |
| SCHEMBL444012 | 0.77 | MAPK1 (0.71) | KMT2AL3MBTL1ALDH1A1MAPK1HIF1A | |
| SCHEMBL8728841 | 0.77 | LMNA (0.53) | KMT2AMEN1L3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL8778114 | 0.76 | MEN1 (0.51) | KMT2AMEN1L3MBTL1ALDH1A1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7417156-B2 | Orally active, antimalarial, anticancer, artemisinin-derived trioxane dimers | JOHNS HOPKINS UNIVERSITY (US) | 2008-08-26 | — | — | US | disclosed |