Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.46 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | STK39 | Q9UEW8 | 1/20 | 0.42 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14083165 | 0.90 | KDR (0.60) | KDRTRPV1GRM4RXFP1FLT1 | |
| SCHEMBL14083344 | 0.89 | TRPV1 (0.49) | KDRTRPV1GRM4RXFP1LMNA | |
| SCHEMBL14083240 | 0.88 | TRPV1 (0.51) | TRPV1GRM4LMNAMAPTPDE4B | |
| SCHEMBL14083162 | 0.85 | TRPV1 (0.62) | KDRTRPV1RXFP1FLT1 | |
| SCHEMBL14083170 | 0.84 | RXFP1 (0.47) | KDRTRPV1RXFP1LMNAMAPT | |
| SCHEMBL14083155 | 0.84 | MAPT (0.50) | KDRTRPV1GRM4LMNAMAPT | |
| SCHEMBL14083371 | 0.83 | TRPV1 (0.61) | TRPV1GRM4LMNAMAPTPDE4B | |
| SCHEMBL14083179 | 0.83 | KDR (0.55) | KDRTRPV1MAPTFLT1 | |
| SCHEMBL14083178 | 0.83 | KMT2A (0.50) | KDRLMNAMAPTS1PR1 | |
| SCHEMBL14083152 | 0.83 | KDR (0.49) | KDRTRPV1RXFP1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080200524-A1 | Amide compounds as ion channel ligands and uses thereof | KELLY MICHAEL G | 2008-08-21 | — | — | US | disclosed |
| US-20080200524-A1 | Amide compounds as ion channel ligands and uses thereof | KELLY MICHAEL G | 2008-08-21 | — | — | US | disclosed |
| US-7338950-B2 | Amide compounds as ion channel ligands and uses thereof | RENOVIS, INC. (US) | 2008-03-04 | — | — | US | disclosed |
| US-7338950-B2 | Amide compounds as ion channel ligands and uses thereof | RENOVIS, INC. (US) | 2008-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080200524-A1 | Amide compounds as ion channel ligands and uses thereof | TRPV1, TRPA1, TRPV2 | KDR 2604/4885TRPV1 1/4885GRM4 362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.