Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 4/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.34 |
| ▸ | NCF1 | P14598 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | RAD52 | P43351 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9023734 | 0.90 | POLB (0.43) | POLBALDH1A1GLAGAATSHR | |
| SCHEMBL9363417 | 0.83 | PDE3B (0.48) | POLBALDH1A1GLAGAATSHR | |
| SCHEMBL9366740 | 0.82 | PDE3B (0.48) | POLBALDH1A1GLAGAATSHR | |
| SCHEMBL9362855 | 0.80 | ALDH1A1 (0.60) | POLBALDH1A1GLAGAATSHR | |
| SCHEMBL9363550 | 0.77 | POLB (0.49) | POLBALDH1A1GLAGAATSHR | |
| SCHEMBL4727878 | 0.77 | SMN1; SMN2 (0.44) | POLBSMN1; SMN2NQO2FERMT2NCF1 | |
| SCHEMBL25873234 | 0.77 | POLB (0.44) | POLBALDH1A1GLAGAATSHR | |
| SCHEMBL1955179 | 0.76 | SMN1; SMN2 (0.63) | POLBALDH1A1SMN1; SMN2 | |
| SCHEMBL9366724 | 0.76 | ALDH1A1 (0.49) | POLBALDH1A1GLAGAATSHR | |
| SCHEMBL15585986 | 0.76 | SMN1; SMN2 (0.46) | POLBSMN1; SMN2NQO2FERMT2NCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1874770-B1 | PHENYLACETAMIDES SUITABLE AS PROTEIN KINASE INHIBITORS | NOVARTIS AG (CH) | 2011-03-09 | — | — | EP | disclosed |