Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.65 |
| ▸ | POLB | P06746 | 2/20 | 0.65 |
| ▸ | CNR1 | P21554 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14517930 | 0.79 | KDM4E (1.00) | KDM4EPOLBRAB9ASMN1; SMN2KMT2A | |
| SCHEMBL22834002 | 0.74 | CNR1 (1.00) | KDM4ECNR1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL4208178 | 0.74 | KDM4E (0.51) | KDM4EPOLBRAB9ASMN1; SMN2KMT2A | |
| SCHEMBL14517931 | 0.73 | KDM4E (0.74) | KDM4EPOLBRAB9ASMN1; SMN2KMT2A | |
| SCHEMBL4704551 | 0.73 | KDM4E (0.49) | KDM4EPOLBRAB9ASMN1; SMN2KMT2A | |
| SCHEMBL5377039 | 0.72 | KDM4E (0.73) | KDM4EPOLBRAB9ASMN1; SMN2KMT2A | |
| SCHEMBL4223869 | 0.72 | CHEK1 (0.53) | KDM4EPOLBCHEK1 | |
| SCHEMBL5377327 | 0.71 | KDM4E (0.67) | KDM4EPOLBRAB9ASMN1; SMN2KMT2A | |
| SCHEMBL5381046 | 0.71 | KDM4E (0.69) | KDM4EPOLBRAB9ASMN1; SMN2KMT2A | |
| SCHEMBL9843028 | 0.69 | CNR1 (0.51) | KDM4ECNR1RAB9ASMN1; SMN2PRKACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7423061-B2 | Substitute thiophenes and uses thereof | ASTRAZENECA AB (SE) | 2008-09-09 | — | — | US | disclosed |