Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4208178 | 0.86 | KDM4E (0.51) | KDM4EPOLBRAB9ASMN1; SMN2KMT2A | |
| SCHEMBL4706363 | 0.80 | KDM4E (0.46) | KDM4EPOLBRAB9ASMN1; SMN2KMT2A | |
| SCHEMBL4703840 | 0.79 | KDM4E (0.45) | KDM4EPOLBRAB9ASMN1; SMN2KMT2A | |
| SCHEMBL4705770 | 0.77 | CHEK1 (0.45) | KDM4EPOLBCHEK1 | |
| SCHEMBL14084408 | 0.73 | KDM4E (0.65) | KDM4EPOLBRAB9ASMN1; SMN2KMT2A | |
| SCHEMBL4223869 | 0.72 | CHEK1 (0.53) | KDM4EPOLBCHEK1 | |
| SCHEMBL4210074 | 0.71 | CHEK1 (0.54) | KDM4EPOLBCHEK1 | |
| SCHEMBL4702659 | 0.71 | CHEK1 (0.58) | KDM4EPOLBRAB9ASMN1; SMN2KMT2A | |
| SCHEMBL4703508 | 0.70 | KDM4E (0.46) | KDM4EPOLBKMT2AMEN1CHEK1 | |
| SCHEMBL4214293 | 0.70 | CHEK1 (0.48) | KDM4EPOLBRAB9ASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660474-B1 | SUBSTITUTED THIOPHENES AND USES THEREOF | ASTRAZENECA AB (SE) | 2008-10-29 | — | — | EP | claimed |