SCHEMBL1408653

SCHEMBL1408653

Cc1ccc2c(c1C)C(C)(C)C1(C=Nc3c(ccc4ccccc34)O1)N2C

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 5/20 0.68
MAPT P10636 5/20 0.68
THRB P10828 4/20 0.68
SMN1; SMN2 Q16637 4/20 0.68
ALOX12 P18054 2/20 0.68
L3MBTL1 Q9Y468 2/20 0.68
PKM P14618 1/20 0.68
HTT P42858 3/20 0.52
ALDH1A1 P00352 2/20 0.52
HPGD P15428 2/20 0.52
LMNA P02545 2/20 0.52
MAPK1 P28482 2/20 0.52
GAA P10253 1/20 0.52
POLB P06746 1/20 0.52
RECQL P46063 1/20 0.52
TDP1 Q9NUW8 1/20 0.52
CYP3A4 P08684 1/20 0.43
CYP2C9 P11712 1/20 0.43
CYP2C19 P33261 1/20 0.43
BLM P54132 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21916975 0.90 MAPT (0.75) KDM4EMAPTTHRBSMN1; SMN2ALOX12
SCHEMBL11071776 0.85 MAPT (0.68) KDM4EMAPTTHRBSMN1; SMN2ALOX12
SCHEMBL10668429 0.85 MAPT (0.48) KDM4EMAPTTHRBSMN1; SMN2ALOX12
SCHEMBL1408846 0.84 MAPT (0.67) KDM4EMAPTTHRBSMN1; SMN2ALOX12
SCHEMBL13619846 0.83 MAPT (0.69) KDM4EMAPTTHRBSMN1; SMN2ALOX12
SCHEMBL14077718 0.83 KDM4E (0.59) KDM4EMAPTTHRBSMN1; SMN2ALOX12
SCHEMBL13619797 0.82 MAPT (0.67) KDM4EMAPTTHRBSMN1; SMN2ALOX12
SCHEMBL6480605 0.82 KDM4E (0.52) KDM4EMAPTTHRBSMN1; SMN2ALOX12
SCHEMBL2401558 0.82 MAPT (0.76) KDM4EMAPTTHRBSMN1; SMN2ALOX12
SCHEMBL13619799 0.82 KDM4E (0.66) KDM4EMAPTTHRBSMN1; SMN2ALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1560060-B1 Polarizing or photochromic plastic lens, coated sheet-like light element and method of its production MGC FILSEET CO LTD (JP) 2011-03-09 EP disclosed
US-7350917-B2 Light control plastic lens, coated sheet-like light control element for the lens production, and a production method for light control plastic lens MGC FILSEET CO., LTD. (JP) 2008-04-01 US disclosed
US-20050168690-A1 Light control plastic lens, coated sheet-like light control element for the lens production, and a production method for light control plastic lens FUJI KASEI CO., LTD. (JP) 2005-08-04 US disclosed
EP-1560060-A1 Polarizing or photochromic plastic lens, coated sheet-like light element and method of its production Fuji Kasei Co., Ltd. (JP) 2005-08-03 EP disclosed
US-20030140934-A1 Wig for decorating hair ADERANS CO., LTD. (JP) 2003-07-31 US disclosed
EP-1275314-A1 WIG FOR DECORATING HAIR ADERANS CO., LTD. (JP) 2003-01-15 EP disclosed
EP-0595424-B1 Composition and procedure for the preparation of organic glasses GREAT LAKES CHEMICAL ITALIA (IT) 1998-05-13 EP disclosed
US-5599876-A POLYMERIZABLE LIQUID CONSISTS OF POLYMERIZABLE POLY(ALLYL CARBONATE) OF ALIPHATIC OR CYCLO-ALIPHATIC POLYOL, AN ORGANIC PEROXIDE GENERATOR OF FREE-RADICALS, AN ORGANIC DYE OR PHOTOCHROMIC COMPOUND ENICHEM SYNTHESIS S.P.A. (IT) 1997-02-04 US disclosed
EP-0595424-A2 Composition and procedure for the preparation of organic glasses GREAT LAKES CHEMICAL ITALIA S.r.l. (IT) 1994-05-04 EP disclosed
EP-0336193-A2 Photocromic nail enamel or varnish and the process for the preparation thereof ENICHEM SYNTHESIS S.p.A. (IT) 1989-10-11 EP disclosed