Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 19/20 | 0.76 |
| ▸ | ABL1 | P00519 | 18/20 | 0.76 |
| ▸ | EGFR | P00533 | 18/20 | 0.76 |
| ▸ | HCK | P08631 | 18/20 | 0.76 |
| ▸ | SRC | P12931 | 18/20 | 0.76 |
| ▸ | KDR | P35968 | 18/20 | 0.76 |
| ▸ | PIK3CA | P42336 | 18/20 | 0.76 |
| ▸ | PIK3CB | P42338 | 18/20 | 0.76 |
| ▸ | MTOR | P42345 | 18/20 | 0.76 |
| ▸ | PIK3CG | P48736 | 18/20 | 0.76 |
| ▸ | PRKDC | P78527 | 18/20 | 0.76 |
| ▸ | EPHB4 | P54760 | 17/20 | 0.76 |
| ▸ | PI4KB | Q9UBF8 | 14/20 | 0.64 |
| ▸ | BTK | Q06187 | 1/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.54 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.54 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.54 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18874474 | 0.89 | PIK3CD (0.72) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL21308414 | 0.84 | SRC (0.59) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL130466 | 0.83 | PIK3CD (0.76) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL14086588 | 0.83 | PIK3CD (0.62) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL3792927 | 0.82 | CYP1A2 (0.69) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL2361494 | 0.81 | KDM4E (0.68) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL16347751 | 0.80 | PIK3CD (0.70) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL14086355 | 0.79 | SRC (0.66) | PIK3CDABL1EGFRSRCPIK3CA | |
| SCHEMBL5066104 | 0.79 | SRC (0.61) | PIK3CDABL1EGFRHCKSRC | |
| SCHEMBL3607753 | 0.78 | PIK3CD (1.00) | PIK3CDABL1EGFRHCKSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429596-B2 | 1H-pyrrolo [2,3-D] pyrimidine derivatives and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2008-09-30 | — | — | US | disclosed |