Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.49 |
| ▸ | PGR | P06401 | 1/20 | 0.49 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.49 |
| ▸ | AR | P10275 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | MIF | P14174 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14092169 | 1.00 | NR3C1 (0.49) | NR3C1PGRNR3C2ARMAOB | |
| SCHEMBL13802627 | 0.89 | NR3C1 (0.49) | NR3C1PGRNR3C2ARMAOB | |
| SCHEMBL13802628 | 0.89 | NR3C1 (0.49) | NR3C1PGRNR3C2ARMAOB | |
| SCHEMBL14092252 | 0.84 | NR3C1 (0.64) | NR3C1PGRNR3C2ARMAOB | |
| SCHEMBL4160752 | 0.80 | AR (0.65) | NR3C1PGRNR3C2ARMAOB | |
| SCHEMBL4165939 | 0.77 | NR3C1 (0.83) | NR3C1PGRNR3C2ARMAOB | |
| SCHEMBL8349726 | 0.77 | NR3C1 (0.83) | NR3C1PGRNR3C2ARMAOB | |
| SCHEMBL4165940 | 0.77 | NR3C1 (0.83) | NR3C1PGRNR3C2ARMAOB | |
| SCHEMBL14092251 | 0.75 | MAOB (0.48) | NR3C1PGRNR3C2ARMAOB | |
| SCHEMBL4161850 | 0.75 | MIF (0.51) | MAOBCYP19A1CYP11B1CYP11B2MIF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7411072-B2 | Tricyclic steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY (US) | 2008-08-12 | — | — | US | disclosed |
| US-7411072-B2 | Tricyclic steroid hormone nuclear receptor modulators | ELI LILLY AND COMPANY (US) | 2008-08-12 | — | — | US | disclosed |