Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | XDH | P47989 | 3/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | HPGDS | O60760 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.43 |
| ▸ | ADH5 | P11766 | 1/20 | 0.42 |
| ▸ | USP1 | O94782 | 1/20 | 0.41 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.41 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21880313 | 0.75 | TP53 (0.61) | TP53NPC1RAB9ANPSR1ALDH1A1 | |
| SCHEMBL12370924 | 0.74 | HCAR2 (0.53) | TP53NPC1RAB9ANPSR1ALDH1A1 | |
| SCHEMBL21880314 | 0.73 | TP53 (0.58) | TP53NPC1RAB9ANPSR1ALDH1A1 | |
| SCHEMBL22915203 | 0.73 | ALDH1A1 (0.72) | TP53NPC1RAB9ANPSR1ALDH1A1 | |
| SCHEMBL14092296 | 0.72 | — | — | |
| SCHEMBL19223934 | 0.71 | TP53 (0.60) | TP53NPC1RAB9ANPSR1ALDH1A1 | |
| SCHEMBL14116389 | 0.70 | PTK2 (0.49) | TP53ALDH1A1PTK2HPGDSHCAR2 | |
| SCHEMBL21880318 | 0.70 | TP53 (0.58) | TP53NPC1RAB9ANPSR1ALDH1A1 | |
| SCHEMBL21880317 | 0.69 | TP53 (0.66) | TP53NPC1RAB9ANPSR1ALDH1A1 | |
| SCHEMBL12303990 | 0.69 | NOTUM (0.59) | TP53NPC1RAB9ANPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7414055-B2 | Inhibitors of Akt activity | MERCK & CO., INC. (US) | 2008-08-19 | — | — | US | disclosed |