Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICAM1 | P05362 | 1/20 | 0.47 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.45 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.40 |
| ▸ | CCR8 | P51685 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13003255 | 0.80 | ACKR3 (0.46) | ICAM1S1PR5ACKR3L3MBTL1S1PR1 | |
| SCHEMBL12533225 | 0.79 | ACKR3 (0.48) | ICAM1S1PR5ACKR3L3MBTL1S1PR1 | |
| SCHEMBL13319011 | 0.78 | L3MBTL1 (0.53) | ICAM1S1PR5ACKR3L3MBTL1HRH3 | |
| SCHEMBL17270120 | 0.75 | ACKR3 (0.74) | ACKR3 | |
| SCHEMBL14456680 | 0.75 | L3MBTL1 (0.53) | ICAM1S1PR5ACKR3L3MBTL1HRH3 | |
| SCHEMBL14095197 | 0.74 | POLB (0.55) | TBK1 | |
| SCHEMBL4114501 | 0.72 | NEK2 (0.52) | CD274NPC1RAB9A | |
| SCHEMBL4002837 | 0.71 | SIGMAR1 (0.59) | S1PR5L3MBTL1HRH3 | |
| SCHEMBL13319465 | 0.71 | ACKR3 (0.46) | ACKR3S1PR1TBK1 | |
| SCHEMBL7234522 | 0.71 | KDR (0.73) | TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008108958-A2 | BENZIMIDAZOLE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION (US) | 2008-09-12 | — | — | WO | disclosed |
| EP-1499316-B1 | (1-4-PIPERIDINYL)BENZIMIDAZOLE DERIVATIVES USEFUL AS HISTAMINE H3 ANTAGONISTS | SCHERING CORP (US) | 2008-03-19 | — | — | EP | disclosed |