Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 17/20 | 0.49 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | HMGCR | P04035 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8949603 | 0.90 | GCGR (0.58) | GCGRMAPK10MAPK14 | |
| SCHEMBL14079242 | 0.89 | GCGR (0.51) | GCGR | |
| SCHEMBL5098482 | 0.84 | GCGR (0.44) | GCGRESR1HMGCRCHRM1TBXA2R | |
| SCHEMBL8949673 | 0.84 | GCGR (0.50) | GCGRMAPK10MAPK14ESR1HMGCR | |
| SCHEMBL9744418 | 0.82 | GCGR (0.54) | GCGRESR1HMGCRCHRM1TBXA2R | |
| SCHEMBL5095278 | 0.81 | GCGR (0.60) | GCGRESR1HMGCRCHRM1TBXA2R | |
| SCHEMBL9744972 | 0.81 | GCGR (0.47) | GCGRMAPK10MAPK14ESR1HMGCR | |
| SCHEMBL5102017 | 0.79 | GCGR (0.49) | GCGR | |
| SCHEMBL9482981 | 0.78 | GCGR (0.47) | GCGRESR1HMGCRCHRM1TBXA2R | |
| SCHEMBL9482986 | 0.78 | GCGR (0.47) | GCGRESR1HMGCRCHRM1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7420059-B2 | HMG-CoA reductase inhibitors and method | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-09-02 | — | — | US | disclosed |