Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 13/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14138155 | 1.00 | ABL1 (0.47) | ABL1 | |
| SCHEMBL14138240 | 0.89 | LCK (0.36) | ABL1 | |
| SCHEMBL14097490 | 0.89 | LCK (0.36) | ABL1 | |
| SCHEMBL14097411 | 0.87 | BCHE (0.34) | ABL1 | |
| SCHEMBL14138378 | 0.84 | LIPG (0.34) | — | |
| SCHEMBL14138220 | 0.84 | LIPG (0.34) | — | |
| SCHEMBL14097504 | 0.82 | ABL1 (0.50) | ABL1 | |
| SCHEMBL14097420 | 0.82 | ABL1 (0.57) | ABL1 | |
| SCHEMBL14138355 | 0.82 | ABL1 (0.57) | ABL1 | |
| SCHEMBL14097445 | 0.79 | ABL1 (0.58) | ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7414046-B2 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-08-19 | — | — | US | disclosed |
| US-7414046-B2 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-08-19 | — | — | US | disclosed |
| US-RE40245-E1 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-15 | — | — | US | disclosed |