Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | TUBB4A | P04350 | 5/20 | 0.35 |
| ▸ | TUBB | P07437 | 5/20 | 0.35 |
| ▸ | TUBA3C | P0DPH7 | 5/20 | 0.35 |
| ▸ | TUBA1B | P68363 | 5/20 | 0.35 |
| ▸ | TUBA4A | P68366 | 5/20 | 0.35 |
| ▸ | TUBB4B | P68371 | 5/20 | 0.35 |
| ▸ | TUBB3 | Q13509 | 5/20 | 0.35 |
| ▸ | TUBB2A | Q13885 | 5/20 | 0.35 |
| ▸ | TUBB8 | Q3ZCM7 | 5/20 | 0.35 |
| ▸ | TUBA3E | Q6PEY2 | 5/20 | 0.35 |
| ▸ | TUBA1A | Q71U36 | 5/20 | 0.35 |
| ▸ | TUBA1C | Q9BQE3 | 5/20 | 0.35 |
| ▸ | TUBB6 | Q9BUF5 | 5/20 | 0.35 |
| ▸ | TUBB2B | Q9BVA1 | 5/20 | 0.35 |
| ▸ | TUBB1 | Q9H4B7 | 5/20 | 0.35 |
| ▸ | ABL1 | P00519 | 6/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14097490 | 1.00 | LCK (0.36) | LCKTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL14097407 | 0.89 | ABL1 (0.47) | ABL1 | |
| SCHEMBL14138155 | 0.89 | ABL1 (0.47) | ABL1 | |
| SCHEMBL14097411 | 0.87 | BCHE (0.34) | ABL1BCHEAAK1TBK1 | |
| SCHEMBL14138220 | 0.85 | LIPG (0.34) | AAK1 | |
| SCHEMBL14138378 | 0.85 | LIPG (0.34) | AAK1 | |
| SCHEMBL14137985 | 0.83 | ABL1 (0.41) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL14097495 | 0.83 | ABL1 (0.41) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL14097751 | 0.82 | TUBB4A (0.43) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL14097460 | 0.81 | TUBB4A (0.41) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7414046-B2 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-08-19 | — | — | US | disclosed |
| US-RE40245-E1 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-15 | — | — | US | disclosed |
| US-RE40245-E1 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-15 | — | — | US | disclosed |