Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 14/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14097427 | 0.83 | PIK3CA (0.52) | ABL1PIK3CAMTORPIK3CG | |
| SCHEMBL14097625 | 0.83 | ABL1 (0.52) | ABL1PIK3CA | |
| SCHEMBL14207570 | 0.82 | ABL1 (0.48) | ABL1 | |
| SCHEMBL14097640 | 0.82 | PDE10A (0.45) | ABL1 | |
| SCHEMBL14097632 | 0.82 | ABL1 (0.41) | ABL1 | |
| SCHEMBL14097624 | 0.77 | ABL1 (0.65) | ABL1 | |
| SCHEMBL14097403 | 0.75 | ABL1 (0.60) | ABL1 | |
| SCHEMBL14097723 | 0.75 | ABL1 (0.48) | ABL1 | |
| SCHEMBL25370002 | 0.74 | MEN1 (0.44) | PIK3CA | |
| SCHEMBL14097621 | 0.74 | ABL1 (0.52) | ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7414046-B2 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-08-19 | — | — | US | disclosed |
| US-7414046-B2 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-08-19 | — | — | US | disclosed |
| US-RE40245-E1 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-15 | — | — | US | disclosed |
| US-RE40245-E1 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-15 | — | — | US | disclosed |
| EP-1341769-B1 | BACTERIAL GYRASE INHIBITORS AND USES THEREOF | VERTEX PHARMA (US) | 2007-10-17 | — | — | EP | disclosed |