Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 14/20 | 0.52 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14097644 | 0.93 | ABL1 (0.56) | ABL1 | |
| SCHEMBL14097643 | 0.92 | ABL1 (0.55) | ABL1 | |
| SCHEMBL14097427 | 0.90 | PIK3CA (0.52) | ABL1PIK3CDPIK3CA | |
| SCHEMBL14097648 | 0.85 | ABL1 (0.50) | ABL1 | |
| SCHEMBL14097674 | 0.84 | ABL1 (0.49) | ABL1 | |
| SCHEMBL14097642 | 0.83 | ABL1 (0.49) | ABL1PIK3CA | |
| SCHEMBL14097444 | 0.82 | ABL1 (0.54) | ABL1 | |
| SCHEMBL14097709 | 0.81 | PIK3CA (0.53) | ABL1PIK3CDPIK3CA | |
| SCHEMBL3659787 | 0.80 | WNT3A (0.51) | ABL1PIK3CDPIK3CA | |
| SCHEMBL14097442 | 0.80 | ABL1 (0.52) | ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7414046-B2 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-08-19 | — | — | US | disclosed |
| US-7414046-B2 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-08-19 | — | — | US | disclosed |
| US-RE40245-E1 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-15 | — | — | US | disclosed |
| US-RE40245-E1 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-15 | — | — | US | disclosed |