Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | FAAH | O00519 | 2/20 | 0.45 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ABL1 | P00519 | 3/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.41 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 1/20 | 0.41 |
| ▸ | CETP | P11597 | 1/20 | 0.41 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.41 |
| ▸ | IL6 | P05231 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14097679 | 0.85 | ABL1 (0.59) | GAAL3MBTL1FAAHSMN1; SMN2ABL1 | |
| SCHEMBL14395652 | 0.79 | GAA (0.48) | GAAL3MBTL1FAAHCHIASMN1; SMN2 | |
| SCHEMBL14097676 | 0.77 | SMN1; SMN2 (0.58) | GAAL3MBTL1FAAHSMN1; SMN2HDAC6 | |
| SCHEMBL12162598 | 0.76 | GAA (0.52) | GAAL3MBTL1FAAHSMN1; SMN2HDAC6 | |
| SCHEMBL14097682 | 0.74 | ABL1 (0.60) | SMN1; SMN2ABL1HDAC6KDM4ENPC1 | |
| SCHEMBL14097401 | 0.73 | ABL1 (0.61) | SMN1; SMN2ABL1KDM4ENPC1MAPT | |
| SCHEMBL14097688 | 0.71 | ABL1 (0.49) | ABL1HDAC6RAB9ACETPIL6 | |
| SCHEMBL14097706 | 0.69 | ABL1 (0.49) | ABL1 | |
| SCHEMBL12545774 | 0.69 | AAK1 (0.60) | GAAL3MBTL1FAAHSMN1; SMN2KDM4E | |
| SCHEMBL1634416 | 0.68 | L3MBTL1 (1.00) | GAAL3MBTL1FAAHSMN1; SMN2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7414046-B2 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-08-19 | — | — | US | disclosed |
| US-7414046-B2 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-08-19 | — | — | US | disclosed |
| US-RE40245-E1 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-15 | — | — | US | disclosed |
| US-RE40245-E1 | Gyrase inhibitors and uses thereof | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2008-04-15 | — | — | US | disclosed |