Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.45 |
| ▸ | CETP | P11597 | 1/20 | 0.44 |
| ▸ | AGPAT2 | O15120 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 2/20 | 0.43 |
| ▸ | IL6 | P05231 | 1/20 | 0.43 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14097679 | 0.81 | ABL1 (0.59) | GAAL3MBTL1HDAC6NPC1RAB9A | |
| SCHEMBL14097676 | 0.80 | SMN1; SMN2 (0.58) | GAAL3MBTL1HDAC6NPC1RAB9A | |
| SCHEMBL14097700 | 0.79 | GAA (0.50) | GAAL3MBTL1HDAC6NPC1RAB9A | |
| SCHEMBL12162598 | 0.74 | GAA (0.52) | GAAL3MBTL1HDAC6NPC1RAB9A | |
| SCHEMBL3476539 | 0.71 | NPC1 (0.58) | GAAHDAC6NPC1RAB9AMEN1 | |
| SCHEMBL14097682 | 0.70 | ABL1 (0.60) | HDAC6NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL22777818 | 0.69 | GAA (0.59) | GAAL3MBTL1HDAC6NPC1RAB9A | |
| SCHEMBL29448067 | 0.69 | GAA (0.59) | GAAL3MBTL1HDAC6NPC1RAB9A | |
| SCHEMBL3476611 | 0.68 | FAAH (0.61) | GAAL3MBTL1HDAC6NPC1RAB9A | |
| SCHEMBL3475420 | 0.68 | HDAC6 (0.67) | GAAL3MBTL1HDAC6NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1341769-B1 | BACTERIAL GYRASE INHIBITORS AND USES THEREOF | VERTEX PHARMA (US) | 2007-10-17 | — | — | EP | disclosed |