Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.45 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.45 |
| ▸ | CALCRL | Q16602 | 10/20 | 0.42 |
| ▸ | RAMP1 | O60894 | 3/20 | 0.42 |
| ▸ | CALCA | P06881 | 1/20 | 0.39 |
| ▸ | CTSS | P25774 | 4/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14098805 | 0.90 | MAPK1 (0.48) | MAPK1PARP1PARP2CALCRLRAMP1 | |
| SCHEMBL14098829 | 0.85 | PARP1 (0.45) | MAPK1PARP1PARP2CALCRLRAMP1 | |
| SCHEMBL14098832 | 0.85 | PARP2 (0.53) | MAPK1PARP1PARP2CALCRLRAMP1 | |
| SCHEMBL14098820 | 0.83 | MAPK1 (0.44) | MAPK1PARP1PARP2CALCRLRAMP1 | |
| SCHEMBL14410174 | 0.82 | CALCRL (0.54) | PARP1PARP2CALCRLRAMP1CTSS | |
| SCHEMBL14098824 | 0.82 | ALOX15 (0.46) | MAPK1PARP1PARP2CALCRLRAMP1 | |
| SCHEMBL14410239 | 0.82 | ESR1 (0.43) | MAPK1PARP1PARP2CALCRLRAMP1 | |
| SCHEMBL14139186 | 0.81 | MAPK1 (0.47) | MAPK1PARP1CALCRLCALCACTSS | |
| SCHEMBL14098830 | 0.80 | CTSD (0.44) | MAPK1PARP1PARP2CALCRLRAMP1 | |
| SCHEMBL14410229 | 0.78 | MAPK1 (0.48) | MAPK1PARP1PARP2CALCRLRAMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7407963-B2 | Cyclopropane CGRP antagonists, medicaments containing these compounds, and method for the production thereof | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2008-08-05 | — | — | US | disclosed |