Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COXFA4 | O00483 | 2/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 11/20 | 0.47 |
| ▸ | EPAS1 | Q99814 | 9/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.46 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12315460 | 0.91 | COXFA4 (0.67) | COXFA4HIF1AEPAS1HSP90AA1 | |
| SCHEMBL14098880 | 0.87 | COXFA4 (0.61) | COXFA4HIF1AEPAS1HSP90AA1 | |
| SCHEMBL12315602 | 0.81 | COXFA4 (0.84) | COXFA4HIF1AEPAS1HSP90AA1EP300 | |
| SCHEMBL14666009 | 0.79 | COXFA4 (0.56) | COXFA4HIF1AEPAS1HSP90AA1 | |
| SCHEMBL12315552 | 0.78 | COXFA4 (0.74) | COXFA4HIF1AHSP90AA1 | |
| SCHEMBL16865491 | 0.76 | COXFA4 (0.59) | COXFA4HIF1AEPAS1HSP90AA1 | |
| SCHEMBL14139182 | 0.76 | COXFA4 (0.65) | COXFA4HIF1AEPAS1HSP90AA1 | |
| SCHEMBL14139181 | 0.76 | COXFA4 (0.65) | COXFA4HIF1AEPAS1HSP90AA1 | |
| SCHEMBL13535021 | 0.76 | COXFA4 (0.65) | COXFA4HIF1AEPAS1HSP90AA1 | |
| SCHEMBL16694415 | 0.76 | HIF1A (0.66) | COXFA4HIF1AEPAS1HSP90AA1EP300 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7410998-B2 | Inhibitors of NADH:ubiquinone oxidoreductase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-08-12 | — | — | US | disclosed |