Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.52 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.46 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14099022 | 0.90 | GAA (0.49) | MAPK1EPHX2NR1H4GAAALDH1A1 | |
| SCHEMBL14099146 | 0.83 | EPHX2 (0.63) | MAPK1EPHX2NR1H4GAAALDH1A1 | |
| SCHEMBL5177709 | 0.83 | GAA (0.74) | MAPK1EPHX2NR1H4GAAALDH1A1 | |
| SCHEMBL4680698 | 0.82 | TRPV1 (0.67) | — | |
| SCHEMBL2955596 | 0.82 | EPHX2 (0.56) | EPHX2NR1H4 | |
| SCHEMBL14532539 | 0.79 | GAA (0.47) | MAPK1EPHX2NR1H4GAAALDH1A1 | |
| SCHEMBL4641693 | 0.79 | MAPK1 (0.50) | MAPK1 | |
| SCHEMBL3567670 | 0.78 | KMT2A (0.73) | MAPK1EPHX2NR1H4GAAALDH1A1 | |
| SCHEMBL14532541 | 0.78 | MAPK1 (0.48) | MAPK1EPHX2NR1H4GAAALDH1A1 | |
| SCHEMBL3928617 | 0.77 | ALDH1A1 (0.59) | MAPK1EPHX2NR1H4GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824837-B1 | SUBSTITUTED N-SULFONYLAMINOBENZYL-2-PHENOXY ACETAMIDE COMPOUNDS | PFIZER (US) | 2008-08-13 | — | — | EP | disclosed |